In our Indianapolis vs Buffalo prediction for Sunday, November 21, 2021, sports bettors have some choices when wagering on the Bills.

Our Indianapolis Colts vs Baltimore Ravens pick has the home team Ravens at -7.0 (-110). On the other hand, you can find the Colts at +8.5 (-130).

Our Tennessee Titans preview 2021 observes that of all the teams in the AFC South, this one has been the most consistent.

Our Jacksonville Jaguars preview 2021 notes that in 2017 this team won 12 of 16 games and took the division title.

In developing our Indianapolis Colts preview 2021, we noted that this team made the playoffs as a wildcard in 2018 and 2020. Both times they won 11 games.

Our Houston Texans preview 2021 notes that last season this team took a mighty fall. In 2018 and 2019, Houston won 11 games each year, finishing atop the AFC South.